AT 1001
CAT:
804-HY-135783-06
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
AT 1001
- CAS Number: 1314801-63-2
- UNSPSC Description: AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) (Ki=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies[1].
- Target Antigen: nAChR
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/at-1001.html
- Smiles: BrC(C=CC=C1)=C1N[C@H]2C[C@@H]3N(C)[C@@H](CCC3)C2
- Molecular Weight: 309.24
- References & Citations: [1]Toll L, et al. AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats[J]. Neuropsychopharmacology, 2012, 37(6): 1367-1376.
- Shipping Conditions: Room Temperature