QS-21

• UNSPSC Description:

  QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].

• Target Antigen:

  NOD-like Receptor (NLR)

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/qs-21.html

• Purity:

  99.67

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C([C@]1(CCC(C)(C)C2)[C@]2([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O[C@@](O[C@H](C(O)=O)[C@@H](O)[C@@H]6O[C@@](OC[C@@H](O)[C@@H]7O)([H])[C@@H]7O)([H])[C@@H]6O[C@]([C@@H]([C@@H](O)[C@H]8O)O)([H])O[C@@H]8CO)[C@@]5(C)C=O)C)[C@]3(C)C[C@H]1O)O[C@H](O[C@H](C)[C@H](OC(C[C@@H](O)C[C@]([C@@H](C)CC)([H])OC(C[C@@H](O)C[C@]([C@@H](C)CC)([H])O[C@@H]9O[C@@H](CO)[C@H](O)[C@H]9O)=O)=O)[C@@H]%10O)[C@@H]%10O[C@@](O[C@@H](C)[C@H](O[C@@](OC[C@@H](O)[C@@H]%11O[C@@](OC[C@]%12(O)CO)([H])[C@@H]%12O)([H])[C@@H]%11O)[C@H]%13O)([H])[C@@H]%13O

• Molecular Weight:

  1990.13

• References & Citations:

  [1]Fernández-Tejada A, et al. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Acc Chem Res. 2016;49(9):1741-1756.|[2]Marty-Roix R, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291(3):1123-1136|[3]Lacaille-Dubois MA. Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review. Phytomedicine. 2019;60:152905.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  Phase 3

• CAS Number:

  141256-04-4