QS-21

• Target:

  Others|||NOD-like Receptor (NLR)

• Related Pathways:

  Others|||Immunology/Inflammation

• Bioactivity:

  QS-21, an immunostimulatory saponin, is a potent vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Furthermore, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1? and IL-18, dependent on caspase-1.

• Smiles:

  [H][C@@] (C[C@H] (O) CC (=O) O[C@@] ([H]) (C[C@H] (O) CC (=O) O[C@H]1[C@@H] (C) O[C@@H] (OC (=O) [C@]23CCC (C) (C) C[C@@]2 ([H]) C2=CC[C@]4 ([H]) [C@@]5 (C) CC[C@H] (O[C@]6 ([H]) O[C@@H] ([C@@H] (O) [C@H] (O[C@]7 ([H]) OC[C@@H] (O) [C@H] (O) [C@H]7O) [C@H]6O[C@]6 ([H]) O[C@H] (CO) [C@H] (O) [C@H] (O) [C@H]6O) C (O) =O) [C@@] (C) (C=O) [C@]5 ([H]) CC[C@@]4 (C) [C@]2 (C) C[C@H]3O) [C@H] (O[C@]2 ([H]) O[C@@H] (C) [C@H] (O[C@]3 ([H]) OC[C@@H] (O) [C@H] (O[C@]4 ([H]) OC[C@] (O) (CO) [C@H]4O) [C@H]3O) [C@@H] (O) [C@H]2O) [C@H]1O) [C@@H] (C) CC) (O[C@@H]1O[C@@H] (CO) [C@H] (O) [C@H]1O) [C@@H] (C) CC

• Molecular Formula:

  C92H148O46

• Molecular Weight:

  1990.15

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  141256-04-4