IL-17C Polyclonal Antibody

The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non‑covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL‑17 RE, have also been reported. Mouse IL-17C cDNA encodes a 194 amino acid (aa) protein with a putative 14 aa signal peptide. Although there are no potential N-linked glycosylation sites, it is reportedly glycosylated. IL-17C shares from 15%‑30% aa sequence identity with other IL-17 family members. Mouse and human IL-17C share 83% aa sequence identity. IL-17C has a very restricted expression pattern and was detected as a rare expressed sequence tag (EST) in an adult prostate and fetal kidney libraries. IL-17C has been shown to stimulate the release of TNF-alpha and IL-1 beta from the monocytic cell line THP-1, a property it shares with IL-17B. Human IL‑17C is active on mouse cells.

IL-17C

Q8K4C5

Human; Rat

Recombinant Mouse IL-17C protein expressed by E.coli

IL17C; CX2; IL-17C; Cytokine CX2; IL 17C; IL 21; Interleukin 17C; Interleukin-17C

Unconjugated

WB

Antigen Affinity Purification

1 mg/mL

WB 1:500-1:1000

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol, pH7.4

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

22 kDa

50 kDa