N-CBZ-Phe-Arg-AMC (TFA)

N-CBZ-Phe-Arg-AMC (TFA)

• UNSPSC Description: N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].
• Target Antigen: Cathepsin
• Type: Peptides
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/n-cbz-phe-arg-amc-tfa.html
• Purity: 99.95
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O)C=C1O4)=CC4=O.OC(C(F)(F)F)=O
• Molecular Weight: 726.70
• References & Citations: [1]Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):246-53.|[2]Porter K,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9(4):581-94.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported