N-CBZ-Phe-Arg-AMC (TFA)

• UNSPSC Description:

  N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].

• Target Antigen:

  Cathepsin

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/n-cbz-phe-arg-amc-tfa.html

• Purity:

  99.95

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O)C=C1O4)=CC4=O.OC(C(F)(F)F)=O

• Molecular Weight:

  726.70

• References & Citations:

  [1]Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):246-53.|[2]Porter K,et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9(4):581-94.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported