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N-CBZ-Phe-Arg-AMC

CAT: 0931-TP1013-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-TP1013-01Size:100 mg
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CAS Number
65147-22-0
Target
Cysteine Protease
Related Pathways
Proteases/Proteasome
Bioactivity
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a substrate for serine proteases, including cathepsins, kallikrein, and plasmin. The substrate exhibits absorption/emission at 330/390 nm (weak fluorescence), while the end product (AMC) shows absorption/emission at 342/441 nm (strong fluorescence) .
Smiles
CC=1C=2C(=CC(NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC(OCC4=CC=CC=C4)=O)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1
Molecular Formula
C33H36N6O6
Molecular Weight
612.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Z-Phe-Arg-Amc HCl
CAS Number65147-22-0
PubChem CID87282815
IUPAC Namebenzyl N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate;hydrochloride
Molecular FormulaC33H37ClN6O6
Molecular Weight649.1
Topological Polar Surface Area187
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Heavy Atom Count46
Formal Charge0
Complexity1080
SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4.Cl
InChI
InChI=1S/C33H36N6O6.ClH/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23;/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36);1H/t26-,27-;/m0./s1
InChIKey
NXIWJKWURGALDP-WMXJXTQLSA-N
Chemical Structure
2D Structure
2D structure of Z-Phe-Arg-Amc HCl
CAS: 65147-22-0
CID: 87282815
Formula: C33H37ClN6O6
MW: 649.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight649.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Exact Mass648.2463106
Monoisotopic Mass648.2463106
Topological Polar Surface Area187 Ų
Heavy Atom Count46
Formal Charge0
Complexity1080
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-P1759N-CBZ-Phe-Arg-AMC
HY-P1759A-01N-CBZ-Phe-Arg-AMC (hydrochloride)
BUP22242-01N-CBZ-Phe-Arg-AMC TFA
BUP05895-01N-CBZ-Phe-Arg-AMC hydrochloride
HY-P1759B-01N-CBZ-Phe-Arg-AMC (TFA)
HY-137199-01Pro-Phe-Arg-AMC
MFR-3095-VZ-Phe-Arg-AMC
4003379.0250Z-Phe-Arg-AMC · HCl
4012340.0025Boc-Phe-Ser-Arg-AMC
I-1295.0250H-Pro-Phe-Arg-AMC

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