Elexacaftor

Elexacaftor

• CAS Number: 2216712-66-0
• UNSPSC Description: Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].
• Target Antigen: Autophagy; CFTR
• Type: Reference compound
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cftr-corrector-1.html
• Purity: 99.74
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2
• Molecular Weight: 597.65
• References & Citations: [1]Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.|[2]Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched