RegisterLogin

Elexacaftor

CAT: 0804-HY-111772-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-111772-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) . Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].
CAS Number
[2216712-66-0]
Product Name Alternative
VX-445
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cftr-corrector-1.html
Purity
99.74
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2
Molecular Formula
C26H34F3N7O4S
Molecular Weight
597.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.|[2]Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379 (17) :1612-1620.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Related Products

CatalogName

Alternative Products

CatalogName
TRC-E201545-0.5MGElexacaftor
TRC-E201547-0.5MGElexacaftor-D3
A20094-50Elexacaftor 50mg
T78240-01(R) -Elexacaftor
A20094-5Elexacaftor 5mg
A20094-10Elexacaftor 10mg
A20094-25Elexacaftor 25mg
MBS5819907(R)-Elexacaftor
A20094-1Elexacaftor 1mg
A20094-100Elexacaftor 100mg

Popular Products