Anti-Ankyrin-B Antibody

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CAT:

14-56518-1

Size:

100 µg

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Anti-Ankyrin-B Antibody

Description: Mouse Monoclonal Antibody specific to Ankyrin-B
Alternative Name: ANK-2, Ankyrin-B, Brain ankyrin, Non-erythroid ankyrin
Gene Name: ANK2
NCBI Gene ID: ANK2
UniProt: Q01484
Cellular Locus: Cytoplasm, cytoskeleton, Membrane, Cytoplasm, myofibril, sarcomere, M line, Apical cell membrane, Cell membrane, Cell junction, synapse, postsynaptic cell membrane, Early endosome, Recycling endosome, Lysosome, Mitochondrion, Cytoplasm, myofibril, sarcomere, Z line, Cell membrane, sarcolemma, T-tubule
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide correspond- ing to aa 203-496 of human Ankyrin-B (accession no. NP_001120965.1)
Target Antigen: Ankyrin-2
Target: Ankyrin-B
Clonality: Monoclonal
Isotype: IgG1
Type: Antibody
Applications: WB, IHC, ICC/IF
Field of Research: Neuroscience
Purification Method: Purified by Protein G affinity chromatography
Concentration: 1.0 mg/mL
Dilution: Dilute in PBS or medium that is identical to that used in the assay system.
Format: Purified
Form: Liquid
Buffer: Phosphate Buffered Saline
Function: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {UniProtKB:Q8C8R3, PubMed:12571597}.
Additionnal Information: Immunoblotting: use at 1-2ug/mL. A band of >200kDa is detected.

Immunohistochemistry: use at 1-5ug/mL.

These are recommended concentrations.

Enduser should determine optimal concentrations for their applications.

Positive control: rat brain membranes.
Storage Conditions: This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.
Specificity: This antibody recognizes human, mouse, and rat Ankyrin-B.
Formulation: PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.Purified by Protein G affinity chromatography.
Buffer pH: pH 7.4
Target Background: Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton. Ankyrins have binding sites for the beta subunit of spectrin and for at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers, and ion transporters in the plasma membrane.

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