EGR-1-IN-1

EGR-1-IN-1

• UNSPSC Description: EGR-1-IN-1 (IT25) is an inhibitor targeting EGR-1, with IC50 of 1.86 μM. EGR-1-IN-1 can be used in the research of inflammatory skin diseases[1].
• Target Antigen: DNA Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/egr-1-in-1.html
• Solubility: DMF : 1.25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: COC1=CC2=C(/C(C(N2)=O)=N/NC(NC3=CC=C(C=C3)C#N)=S)C=C1
• Molecular Weight: 351.38
• References & Citations: [1]Ahn S, et al. Design, synthesis, and biological evaluation of 2-(2-oxoindolin-3-ylidene)hydrazinecarbothioamides as a potential EGR-1 inhibitor for targeted therapy of atopic dermatitis. Bioorg Chem. 2024 Jul;148:107481.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported