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THZ2

CAT: 0804-HY-12280-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12280-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THZ2 is a potent and selective CDK7 inhibitor with an IC50 of 13.9 nM.
CAS Number
[1604810-84-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/THZ2.html
Purity
99.03
Solubility
DMSO : 21.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN(C)C)=O)=C5
Molecular Formula
C31H28ClN7O2
Molecular Weight
566.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang Y, et al. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer. Cell. 2015 Sep 24;163 (1) :174-186.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5; CDK7; CDK8; CDK9

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