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THZ-P1-2

CAT: 0804-HY-136351-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136351-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1].
CAS Number
2058075-45-7
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thz-p1-2.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(C=C1)=CC=C1NC(/C=C/CN(C)C)=O)NC2=CC=CC(NC3=CC(C4=CNC5=CC=CC=C45)=NC=N3)=C2
Molecular Formula
C31H29N7O2
Molecular Weight
531.61
References & Citations
[1]Sivakumaren SC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020;27 (5) :525‐537.e6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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