Cotinine (Standard)

• Description:

  Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-) -Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke[1]

• Product Name Alternative:

  (-) -Cotinine (Standard) ; (S) -Cotinine (Standard) ; NIH-10498 (Standard)

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite; nAChR; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/cotinine-standard.html

• Smiles:

  O=C1N(C)[C@H](C2=CC=CN=C2)CC1

• Molecular Formula:

  C10H12N2O

• Molecular Weight:

  176.22

• References & Citations:

  [1]Dolcini MM, et al. An assessment of the validity of adolescent self-reported smoking using three biological indicators. Nicotine Tob Res. 2003 Aug;5 (4) :473-83.|[2]Sastry BV, et al. Distribution and retention of nicotine and its metabolite, cotinine, in the rat as a function of time. Pharmacology. 1995 Feb;50 (2) :128-36.|[3]Borzelleca J F, et al. Studies on the respiratory and cardiovascular effects of (-) -cotinine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 137 (3) : 313-318.|[4]Dwoskin L P, et al. (S) - (−) -Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H] dopamine release from rat striatal slices in a calcium-dependent manner[J]. Journal of pharmacology and experimental therapeutics, 1999, 288 (3) : 905-911.|[5]Yang Q, et al. Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [486-56-6]