Cotinine (Standard)

CAT: 0804-HY-B1178R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1178R-01Size:5 mg
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Description
Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-) -Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke[1]
CAS Number
[486-56-6]
Product Name Alternative
(-) -Cotinine (Standard) ; (S) -Cotinine (Standard) ; NIH-10498 (Standard)
UNSPSC
12352005
Target
Endogenous Metabolite; nAChR; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cotinine-standard.html
Smiles
O=C1N(C)[C@H](C2=CC=CN=C2)CC1
Molecular Formula
C10H12N2O
Molecular Weight
176.22
References & Citations
[1]Dolcini MM, et al. An assessment of the validity of adolescent self-reported smoking using three biological indicators. Nicotine Tob Res. 2003 Aug;5 (4) :473-83.|[2]Sastry BV, et al. Distribution and retention of nicotine and its metabolite, cotinine, in the rat as a function of time. Pharmacology. 1995 Feb;50 (2) :128-36.|[3]Borzelleca J F, et al. Studies on the respiratory and cardiovascular effects of (-) -cotinine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 137 (3) : 313-318.|[4]Dwoskin L P, et al. (S) - (−) -Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H] dopamine release from rat striatal slices in a calcium-dependent manner[J]. Journal of pharmacology and experimental therapeutics, 1999, 288 (3) : 905-911.|[5]Yang Q, et al. Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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