R-(+)-Cotinine

• UNSPSC Description:

  R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].

• Target Antigen:

  nAChR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/r-plus-cotinine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C)[C@@H](C2=CC=CN=C2)CC1

• Molecular Weight:

  176.22

• References & Citations:

  [1]Jr AVT, et, al. R-(+) and S-(-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352(2):405-18.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  32162-64-4