R- (+) -Cotinine

• Description :

  R- (+) -Cotinine ((+) -Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R- (+) -Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].

• Product Name Alternative :

  (+) -Cotinine; (R) -Cotinine; (R) -NIH-10498

• UNSPSC :

  12352005

• Target :

  NAChR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/r-plus-cotinine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C)[C@@H](C2=CC=CN=C2)CC1

• Molecular Formula :

  C10H12N2O

• Molecular Weight :

  176.22

• References & Citations :

  [1]Jr AVT, et, al. R- (+) and S- (-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352 (2) :405-18.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [32162-64-4]