Aurora Kinases-IN-3
CAT:
804-HY-151971-05
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Aurora Kinases-IN-3
- CAS Number: 2840558-83-8
- UNSPSC Description: Aurora Kinases-IN-3 (Compound 15a) is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10[1].
- Target Antigen: Aurora Kinase; Polo-like Kinase (PLK)
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/aurora-kinases-in-3.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CNC(C1=CC(OC(F)(F)F)=CC(OC2=C(C=CC=N2)C3=CC(OC)=NC=C3)=C1)=O
- Molecular Weight: 419.35
- References & Citations: [1]Lv G, et al. 2-Phenoxy-3, 4'-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114904.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported