Aurora Kinases-IN-2

Aurora Kinases-IN-2

• CAS Number: 2241914-86-1
• UNSPSC Description: Aurora Kinases-IN-2 (compound 12Aj) is a potent Aurora kinases inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used for cancer research[1].
• Target Antigen: Aurora Kinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/aurora-kinases-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=CC(Cl)=C1)C2=CC=C(OC3=NC(C4=C(C)ON=C4C)=CN=C3N)C=C2
• Molecular Weight: 435.86
• References & Citations: [1]Bo YX, et, al. Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors. Bioorg Med Chem. 2020 Mar 1;28(5):115351.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported