Aurora Kinases-IN-4

Aurora Kinases-IN-4

• CAS Number: 2877011-84-0
• UNSPSC Description: Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].
• Target Antigen: Aurora Kinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/aurora-kinases-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: CN1CCN(C2=CC(N=C(C3=CC=C(NC(C=C)=O)C=C3)N=C4NC5=NNC(C)=C5)=C4C=C2)CC1
• Molecular Weight: 468.55
• References & Citations: [1]Zhang B, et al. Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer. Eur J Med Chem. 2023 Aug 5;256:115457.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported