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MeS-IMPY

CAT: 0804-HY-167898Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-167898Size:1 Each
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Description
MeS-IMPY is a ligand of β-amyloid plaques. MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (Ki=7.93 and 8.95 nM, respectively) . [11C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET) [1][2].
CAS Number
955376-42-8
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mes-impy.html
Smiles
CSC1=CN2C=C(C3=CC=C(N(C)C)C=C3)N=C2C=C1
Molecular Formula
C16H17N3S
Molecular Weight
283.39
References & Citations
[1]Seneca N, et al. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. Nucl Med Biol. 2007 Aug;34 (6) :681-9.|[2]Seneca N, et al. Low retention of [S-methyl-11C] MeS-IMPY to β-amyloid plaques in patients with Alzheimer's disease[J]. Current Radiopharmaceuticals, 2009, 2 (2) : 129-136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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