MeS-IMPY

• UNSPSC Description:

  MeS-IMPY is a ligand of β-amyloid plaques. MeS-IMPY shows a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (Ki=7.93 and 8.95 nM, respectively). [11C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET)[1][2].

• Target Antigen:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mes-impy.html

• Smiles:

  CSC1=CN2C=C(C3=CC=C(N(C)C)C=C3)N=C2C=C1

• Molecular Weight:

  283.39

• References & Citations:

  [1]Seneca N, et al. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. Nucl Med Biol. 2007 Aug;34(6):681-9.|[2]Seneca N, et al. Low retention of [S-methyl-11C] MeS-IMPY to β-amyloid plaques in patients with Alzheimer's disease[J]. Current Radiopharmaceuticals, 2009, 2(2): 129-136.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  955376-42-8