CPTH2
CAT:
804-HY-W013274-03
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CPTH2
- CAS Number: 357649-93-5
- UNSPSC Description: CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
- Target Antigen: Apoptosis; Histone Acetyltransferase
- Type: Reference compound
- Related Pathways: Apoptosis;Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cpth2.html
- Purity: 99.82
- Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 1 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic)
- Smiles: ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1
- Molecular Weight: 291.80
- References & Citations: [1]Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44.|[2]Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported