Mavacamten

Mavacamten

• CAS Number: 1642288-47-8
• UNSPSC Description: Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
• Target Antigen: Myosin
• Type: Reference compound
• Related Pathways: Cytoskeleton
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Mavacamten.html
• Purity: 99.94
• Solubility: DMSO : 83.33 mg/mL (ultrasonic)
• Smiles: CC(N(C1=O)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O)C
• Molecular Weight: 273.336
• References & Citations: [1]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292(40):16571-16577.|[2]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11(12):e0168407.|[3]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: Launched