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U0124

CAT: 0804-HY-107621-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107621-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1].
CAS Number
108923-79-1
UNSPSC
12352211
Hazard Statement
H301, H315, H319, H335
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/u0124.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC(/C(C#N)=C(N)/SC)=C(N)\SC
Molecular Formula
C8H10N4S2
Molecular Weight
226.32
Precautions
H301, H315, H319, H335
References & Citations
[1]M F Favata, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273 (29) :18623-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene
CAS Number108923-79-1
PubChem CID5842955
IUPAC Name(2Z,3Z)-2,3-bis[amino(methylsulfanyl)methylidene]butanedinitrile
Molecular FormulaC8H10N4S2
Molecular Weight226.3
XLogP0.2
Topological Polar Surface Area150
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count14
Formal Charge0
Complexity339
SMILES
CS/C(=C(/C(=C(/SC)\N)/C#N)\C#N)/N
InChI
InChI=1S/C8H10N4S2/c1-13-7(11)5(3-9)6(4-10)8(12)14-2/h11-12H2,1-2H3/b7-5+,8-6+
InChIKey
LBQNBMSPTURKGS-KQQUZDAGSA-N
Chemical Structure
2D Structure
2D structure of 1,4-Diamino-2,3-dicyano-1,4-bis(methylthio)butadiene
CAS: 108923-79-1
CID: 5842955
Formula: C8H10N4S2
MW: 226.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight226.3
XLogP30.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass226.03468868
Monoisotopic Mass226.03468868
Topological Polar Surface Area150 Ų
Heavy Atom Count14
Formal Charge0
Complexity339
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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