20S Proteasome activator 1

20S Proteasome activator 1

• CAS Number: 2761578-18-9
• UNSPSC Description: 20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases[1].
• Target Antigen: Proteasome
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/20s-proteasome-activator-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)CCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35
• Molecular Weight: 492.97
• References & Citations: [1]Staerz SD, et al. Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies. J Med Chem. 2022 May 12;65(9):6631-6642.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported