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20S Proteasome activator 1

CAT: 0931-T63321-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T63321-01Size:5 mg
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CAS Number
2761578-18-9
Target
Proteasome
Related Pathways
Proteases/Proteasome, Ubiquitination
Purity
0.9982
Bioactivity
20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases.
Smiles
C(CC(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)=O)N3C=4C(SC=5C3=CC=CC5)=CC=C(Cl)C4
Molecular Formula
C27H19ClF2N2OS
Molecular Weight
492.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

20S Proteasome activator 1
CAS Number2761578-18-9
PubChem CID164886633
IUPAC Name3-(2-chlorophenothiazin-10-yl)-N,N-bis(4-fluorophenyl)propanamide
Molecular FormulaC27H19ClF2N2OS
Molecular Weight493.0
XLogP7.5
Topological Polar Surface Area48.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity664
SMILES
C1=CC=C2C(=C1)N(C3=C(S2)C=CC(=C3)Cl)CCC(=O)N(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
InChI
InChI=1S/C27H19ClF2N2OS/c28-18-5-14-26-24(17-18)31(23-3-1-2-4-25(23)34-26)16-15-27(33)32(21-10-6-19(29)7-11-21)22-12-8-20(30)9-13-22/h1-14,17H,15-16H2
InChIKey
ZFFNQHQEQWDWBM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 20S Proteasome activator 1
CAS: 2761578-18-9
CID: 164886633
Formula: C27H19ClF2N2OS
MW: 493.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight493.0
XLogP37.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass492.0874684
Monoisotopic Mass492.0874684
Topological Polar Surface Area48.9 Ų
Heavy Atom Count34
Formal Charge0
Complexity664
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
330764PSME4 (Proteasome activator complex subunit 4, Proteasome activator PA200, KIAA0077)
HY-150602-0120S Proteasome activator 1
350490-01PSME4, NT (Proteasome activator complex subunit 4, Proteasome activator PA200, KIAA0077)
abx262930-01Proteasome Activator Subunit 2 Protein
330784-01Proteasome activator complex subunit 3
DF13732-BPProteasome Activator Subunit 4 Peptide
DF13732-01Proteasome Activator Subunit 4 Antibody
AS19 4269Anti-PA200 | Proteasome activator PA200
abx262934-01Proteasome Activator Subunit 3 Protein
489646PSME2 (Proteasome Activator Complex Subunit 2, Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 beta)

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