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SJ46411

CAT: 0804-HY-168536Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168536Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJ46411 is a potent ligand for KLHDC2, with a Kd of ~260 nM measured by isothermal titration calorimetry (SPR Kd = 0.5 μM, TR-FRET IC50 = 3.9 μM, ΔTm = 6.0 °C) [1].
CAS Number
3086104-39-1
UNSPSC
12352211
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj46411.html
Smiles
O=C(CNC(CC1=CSC(C2=CC=C3C=CC=CC3=C2)=N1)=O)O
Molecular Formula
C17H14N2O3S
Molecular Weight
326.37
References & Citations
[1]Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15 (1) :8829. doi: 10.1038/s41467-024-52966-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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