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SJ46420

CAT: 0804-HY-168635Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168635Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJ46420, a SJ46421 pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-13030) ; Black: linker (HY-20797) ; Blue: E3 ligase ligand (HY-159973) ).
UNSPSC
12352211
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj46420.html
Smiles
O=C(OC)CNC(CC1=CSC(C2=CC=C3C=CC=C(OCCN4CCN(C(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)CC4)C3=C2)=N1)=O
Molecular Formula
C43H43ClN8O5S2
Molecular Weight
851.44
References & Citations
[1]Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15 (1) :8829.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD3; von Hippel-Lindau (VHL)

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HY-168634SJ46421
HY-168536SJ46411
HY-168646SJ46411-Br
HY-159973Me-SJ46411
HY-159974Me-SJ46411-PEG1-Piperazine-Boc

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CatalogName
GTR19239668-01SJ46420

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