Moracin M

• Description:

  Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Autophagy; Endogenous Metabolite; NF-κB; Phosphodiesterase (PDE)

• Type:

  Natural Products

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/moracin-m.html

• Concentration:

  10mM

• Purity:

  98.99

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1

• Molecular Formula:

  C14H10O4

• Molecular Weight:

  242.23

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Chen SK, et al. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2012 May 1;22 (9) :3261-4.|[2]Lee JH, et al. Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo. Eur J Pharmacol. 2016;783:64-72.|[3]Guo F, et al. Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation. Int Immunopharmacol. 2018 May;58:80-86.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  PDE4; PDE5; PDE9

• CAS Number:

  [56317-21-6]