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Moracin M

CAT: 0804-HY-122942-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122942-01Size:5 mg
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Description
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity[1][2].
CAS Number
56317-21-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Autophagy; Endogenous Metabolite; NF-κB; Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Autophagy; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/moracin-m.html
Concentration
10mM
Purity
98.99
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1
Molecular Formula
C14H10O4
Molecular Weight
242.23
Precautions
H315, H319, H335
References & Citations
[1]Chen SK, et al. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2012 May 1;22 (9) :3261-4.|[2]Lee JH, et al. Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo. Eur J Pharmacol. 2016;783:64-72.|[3]Guo F, et al. Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation. Int Immunopharmacol. 2018 May;58:80-86.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PDE4; PDE5; PDE9

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