Moracin P

• Description :

  Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1) . Moracin P reduces oxygen-glucose deprivation (OGD) -induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/moracin-p.html

• Purity :

  99.62

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O[C@@H]1CC2=C(OC1(C)C)C=C(OC(C3=CC(O)=CC(O)=C3)=C4)C4=C2

• Molecular Formula :

  C19H18O5

• Molecular Weight :

  326.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD) -induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34 (8) :1373-80.|[2]Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46 (6) :2386-96.|[3]Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22 (6) :5385-5391.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [102841-46-3]