Sgc8c-M

• Description :

  Sgc8c-M is a PTK7-targeted aptamer-drug conjugate (ApDC) . Sgc8c-M is composed of the classic PTK7-specific aptamer Sgc8c, a cathepsin B (CTSB) -cleavable valine-citrulline (VC) -based linker, and the potent antimitotic agent Monomethyl auristatin E (MMAE) (HY-15162) as the payload. Sgc8c-M inhibits the growth of PTK7-overexpressing cancer cells. Sgc8c-M can be used for the study of PTK7-expressing advanced solid tumors[1].

• Target :

  Others

• Related Pathways :

  Others

• Field of Research :

  Cancer

• Smiles :

  [Sgc8c-M]

• References & Citations :

  [1]Su M, et al. An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates. Signal Transduct Target Ther. 2025 Sep 24;10 (1) :316.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported