L-Thyroxine sodium xhydrate

L-Thyroxine sodium xhydrate

• CAS Number: 25416-65-3
• UNSPSC Description: L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
• Target Antigen: Thyroid Hormone Receptor
• Type: Biochemical Assay Reagents
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/L-Thyroxine_sodium_xhydrate.html
• Purity: 99.30
• Solubility: 0.01 M NaOH : 2 mg/mL (ultrasonic;warming;adjust pH to 12 with NaOH;heat to 60°C)
• Smiles: IC1=C(O)C(I)=CC(OC2=C(I)C=C(C[C@@](N)([H])C(O[Na])=O)C=C2I)=C1.O
• Molecular Weight: 816.87
• References & Citations: [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Jan 11.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 4