WKYMVM-NH2 (TFA)

CAT: 0804-HY-P1121A-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-P1121A-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3].

CAS Number

1435781-74-0

UNSPSC

12352209

Target

Formyl Peptide Receptor (FPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/wkymvm-nh2-tfa.html

Purity

99.67

Solubility

H2O : 12.5 mg/mL (ultrasonic)

Smiles

CSCC[C@@H](C(N)=O)NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H](CC1=CC=C(C=C1)O)NC([C@H](CCCCN)NC([C@H](CC2=CNC3=CC=CC=C23)N)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F

Molecular Formula

C43H62F3N9O9S2

Molecular Weight

970.13

References & Citations

[1]Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276 (24) :21585-93.|[2]Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56 (5) :470-6.|[3]Sang Doo Kim, et al. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Exp Mol Med. 2013 Sep; 45 (9) : e40.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Chemical Information

Wkymvm-NH2 (tfa)

CAS Number	1435781-74-0
PubChem CID	71312038
IUPAC Name	(2S)-6-amino-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]hexanamide;2,2,2-trifluoroacetic acid
Molecular Formula	C43H62F3N9O9S2
Molecular Weight	970.1
Topological Polar Surface Area	365
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	26
Heavy Atom Count	66
Formal Charge	0
Complexity	1440

SMILES

CC(C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N.C(=O)(C(F)(F)F)O

InChI

InChI=1S/C41H61N9O7S2.C2HF3O2/c1-24(2)35(41(57)46-31(36(44)52)16-19-58-3)50-39(55)33(17-20-59-4)48-40(56)34(21-25-12-14-27(51)15-13-25)49-38(54)32(11-7-8-18-42)47-37(53)29(43)22-26-23-45-30-10-6-5-9-28(26)30;3-2(4,5)1(6)7/h5-6,9-10,12-15,23-24,29,31-35,45,51H,7-8,11,16-22,42-43H2,1-4H3,(H2,44,52)(H,46,57)(H,47,53)(H,48,56)(H,49,54)(H,50,55);(H,6,7)/t29-,31-,32-,33-,34-,35-;/m0./s1

InChIKey

MYVYQWVNXDVTBW-CZPFDPCBSA-N

Chemical Structure

2D Structure

CAS: 1435781-74-0

CID: 71312038

Formula: C43H62F3N9O9S2

MW: 970.1

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	970.1
Hydrogen Bond Donor Count	11
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	26
Exact Mass	969.40640142
Monoisotopic Mass	969.40640142
Topological Polar Surface Area	365 Å²
Heavy Atom Count	66
Formal Charge	0
Complexity	1440
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-P1121	WKYMVM-NH2
HY-P1120A	WKYMVm (TFA)
HY-P10930A-01	Wrwycr-NH2 (TFA)
HY-P1311A	RLLFT-NH2 (TFA)
HY-P1187A	HSDVHK-NH2 (TFA)
HY-P1312A-01	LRGILS-NH2 (TFA)
HY-P10930-01	Wrwyar-NH2 (TFA)
HY-153552A-01	NH2-UAMC1110 (TFA)
HY-P0226A-01	TFLLR-NH2 (TFA)
HY-P1310A	VKGILS-NH2 (TFA)

Alternative Products

Catalog	Name
MBS5817723	WKYMVM-NH2 TFA
TP1476-01	WKYMVM TFA
257108	WKYMVM (Trp-Lys-Tyr-Met-Val-D-Met-NH2 TFA) discontinued
B5703-1	FSLLRY-NH2 TFA
TP1334-01	TFLLR-NH2 (TFA)
T75903-01	VKGILS-NH2 TFA
T75874-01	TcY-NH2 TFA
MBS5822711	SWELYYPLRANL-NH2 TFA
MBS5817807	SLIGRL-NH2 TFA
GTR19215781-01	Mal-NH2 TFA

WKYMVM-NH2 (TFA)

Chemical Information

Related Products

Alternative Products

Popular Products