WKYMVM-NH2

CAT: 0804-HY-P1121Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P1121Size:1 Each
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Description
WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells via the FPRL1 and FPRL2 receptors. It exhibits EC50 values of 2 nM and 80 nM in HL-60-FPRL1 and HL-60-FPRL2 cells, respectively. In HL-60 cells stably expressing FPRL2, WKYMVM-NH₂ induces chemotaxis, with optimal migration observed at concentrations ranging from 10 to 50 nM. It also stimulates superoxide production in neutrophils, with an EC50 of 75 nM. WKYMVM-NH₂ is a useful tool for research in the field of inflammatory diseases[1].
CAS Number
[187986-11-4]
UNSPSC
12352209
Target
Formyl Peptide Receptor (FPR)
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O
Molecular Formula
C41H61N9O7S2
Molecular Weight
856.11
References & Citations
[1]Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276 (24) :21585-93.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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