WKYMVM-NH2

• Description:

  WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells via the FPRL1 and FPRL2 receptors. It exhibits EC50 values of 2 nM and 80 nM in HL-60-FPRL1 and HL-60-FPRL2 cells, respectively. In HL-60 cells stably expressing FPRL2, WKYMVM-NH₂ induces chemotaxis, with optimal migration observed at concentrations ranging from 10 to 50 nM. It also stimulates superoxide production in neutrophils, with an EC50 of 75 nM. WKYMVM-NH₂ is a useful tool for research in the field of inflammatory diseases[1].

• UNSPSC:

  12352209

• Target:

  Formyl Peptide Receptor (FPR)

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  OC (C=C1) =CC=C1C[C@@H] (C (N[C@@H] (CCSC) C (N[C@@H] (C (C) C) C (N[C@H] (C (N) =O) CCSC) =O) =O) =O) NC ([C@H] (CCCCN) NC ([C@@H] (N) CC2=CNC3=CC=CC=C23) =O) =O

• Molecular Formula:

  C41H61N9O7S2

• Molecular Weight:

  856.11

• References & Citations:

  [1]Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276 (24) :21585-93.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  187986-11-4