Leucinostatin A

CAT: 0804-HY-P2450Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P2450Size:1 Each
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Description
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].
CAS Number
[76600-38-9]
Product Name Alternative
Antibiotic P168
UNSPSC
12352211
Target
Antibiotic; Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/leucinostatin-a.html
Solubility
10 mM in DMSO
Smiles
[P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}]
Molecular Formula
C62H111N11O13
Molecular Weight
1218.61
References & Citations
[1]Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221 (2) :125-132. |[2]Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275 (1-2) :61-72. |[3]Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60 (28) :15613-15621.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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