D-AP7

• Description:

  D-AP7 is a specific NMDA receptor antagonist with inhibitory activity against epileptiform activity. D-AP7 attenuated neuronal activation in spot activity by reducing the duration and number of exogenously induced bursts. D-AP7 also increased the amplitude of secondary action potentials, which may restore neuronal activity in some epileptiform bursts. D-AP7 showed anxiogenic effects and impaired memory consolidation in passive avoidance learning[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H315-H319-H335

• Target:

  IGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-ap7.html

• Smiles:

  OC([C@H](N)CCCCCP(O)(O)=O)=O

• Molecular Formula:

  C7H16NO5P

• Molecular Weight:

  225.18

• Precautions:

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]NMDA receptor antagonists attenuate a portion of the penicillin-induced epileptiform burst

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [81338-23-0]