DL-Buthionine-(S,R)-sulfoximine
CAT:
804-HY-106376-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DL-Buthionine-(S,R)-sulfoximine
- CAS Number: 5072-26-4
- UNSPSC Description: DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
- Target Antigen: Ferroptosis
- Type: Reference compound
- Related Pathways: Apoptosis
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/D,L-Buthionine-_S,R_-sulfoximine.html
- Purity: 99.67
- Solubility: H2O : 25 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: OC(C(N)CCS(CCCC)(=N)=O)=O
- Molecular Weight: 222.31
- References & Citations: [1]Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60.|[2]Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported