L-Buthionine-(S,R)-sulfoximine (hydrochloride)

L-Buthionine-(S,R)-sulfoximine (hydrochloride)

• UNSPSC Description: L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively[1][2].
• Target Antigen: Ferroptosis
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/l-buthionine-s-r-sulfoximine-hydrochloride.html
• Purity: 98.0
• Solubility: H2O : 70 mg/mL (ultrasonic)
• Smiles: N[C@H](C(O)=O)CCS(CCCC)(=O)=N.[H]Cl
• Molecular Weight: 258.77
• References & Citations: [1]Fruehauf JP, et al. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res. 1997 Aug;10(4):236-49.|[2]Reliene R, et al. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis. 2006 Feb;27(2):240-4.|[3]Satoru Nishizawa, et al. Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors. Oncol Lett. 2018 Jun;15(6):8735-8743.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported