L-Methionine-DL-sulfoximine

• UNSPSC Description:

  L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS)[1][2][3][4][5].

• Target Antigen:

  Glutaminase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/l-methionine-dl-sulfoximine.html

• Purity:

  98.0

• Solubility:

  DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(O)[C@@H](N)CCS(=N)(C)=O

• Molecular Weight:

  180.23

• References & Citations:

  [1]Albrecht J, Norenberg MD. L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture. Eur J Pharmacol. 1990;182(3):587-589. |[2]Premakumar R, Sorger GJ, Gooden D. Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b. J Bacteriol. 1980;143(1):411-415. |[3]Pawlik MJ, et al. Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats[J]. Brain Res. 2021 Feb 15;1753:147253. |[4]Prakash, O., et al. Isolation and Characterization of Ammonia Secreting Cyanobacterium Nostoc sp. NDUPC007 from Agriculture Fields of Varanasi[J]. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 2022 January 10; 92, 89–93. |[5]Pawlik MJ, et al. Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose[J]. Int J Mol Sci. 2021 Oct 15;22(20):11127.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  15985-39-4