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Kartogenin (sodium)

CAT: 0804-HY-16268A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16268A-01Size:5 mg
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Description
Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM) . Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research[1][2][3][4].
CAS Number
1401168-39-5
Product Name Alternative
KGN (sodium)
UNSPSC
12352005
Target
TGF-beta/Smad
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kartogenin-sodium.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O
Molecular Formula
C20H14NNaO3
Molecular Weight
339.32
References & Citations
[1]Cai J, Zhang L, Chen J, et al. Kartogenin and its application in regenerative medicine[J]. Current medical science, 2019, 39 (1) : 16-20.|[2]Zhang J, Wang J H C. Kartogenin induces cartilage-like tissue formation in tendon–bone junction[J]. Bone research, 2014, 2 (1) : 1-10.|[3]Johnson K, et, al. A stem cell-based approach to cartilage repair. Science. 2012 May 11;336 (6082) :717-21.|[4]Liu F, et, al. A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Stem Cell Res Ther. 2019 Jul 8;10 (1) :201.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Kartogenin sodium
CAS Number1401168-39-5
PubChem CID140639031
IUPAC Namesodium 2-[(4-phenylphenyl)carbamoyl]benzoate
Molecular FormulaC20H14NNaO3
Molecular Weight339.3
Topological Polar Surface Area69.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity442
SMILES
C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3C(=O)[O-].[Na+]
InChI
InChI=1S/C20H15NO3.Na/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14;/h1-13H,(H,21,22)(H,23,24);/q;+1/p-1
InChIKey
LNDQCRAZLSOXTG-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Kartogenin sodium
CAS: 1401168-39-5
CID: 140639031
Formula: C20H14NNaO3
MW: 339.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight339.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass339.08713759
Monoisotopic Mass339.08713759
Topological Polar Surface Area69.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity442
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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