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Kartogenin

CAT: 0804-HY-16268-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16268-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM) . Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research[1][2][3][4].
CAS Number
4727-31-5
Product Name Alternative
KGN
UNSPSC
12352005
Hazard Statement
H302, H319, H410
Target
TGF-beta/Smad
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Kartogenin.html
Purity
99.05
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 10 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O
Molecular Formula
C20H15NO3
Molecular Weight
317.34
Precautions
H302, H319, H410
References & Citations
[1]Johnson K, et, al. A stem cell-based approach to cartilage repair. Science. 2012 May 11;336 (6082) :717-21.|[2]Liu F, et, al. A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Stem Cell Res Ther. 2019 Jul 8;10 (1) :201.|[3]Cai J, Zhang L, Chen J, et al. Kartogenin and its application in regenerative medicine[J]. Current medical science, 2019, 39 (1) : 16-20.|[4]Zhang J, Wang J H C. Kartogenin induces cartilage-like tissue formation in tendon–bone junction[J]. Bone research, 2014, 2 (1) : 1-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
510310Kartogenin

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