UCL-1848 (TFA)

CAT: 0804-HY-122104Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-122104Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

UCL-1848 TFA is a hSK1 blocker with an IC50 value of 1.1 nM. hSK1 is a small conductance calcium-activated potassium channel[1].

CAS Number

201147-53-7

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ucl-1848-tfa.html

Smiles

O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F.C1(NCCCCCNC2=C3C=CC=CC3=[N+]4C=C2)=CC=[N+](CCCCC4)C5=CC=CC=C15

Molecular Formula

C32H34F6N4O4

Molecular Weight

652.63

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shah M, et al. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129 (4) :627-30.|[2]Chen JQ, et al. bis-Quinolinium cyclophanes: 8,14-diaza-1,7 (1, 4) -diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca (2+) -activated K (+) channel. J Med Chem. 2000 Sep 21;43 (19) :3478-81.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Ucl1848

CAS Number	201147-53-7
PubChem CID	9811445
IUPAC Name	15,21-diaza-1,7-diazoniapentacyclo[20.6.2.27,14.08,13.023,28]dotriaconta-1(29),7(32),8,10,12,14(31),22(30),23,25,27-decaene
Molecular Formula	C28H34N4+2
Molecular Weight	426.6
XLogP	6.2
Topological Polar Surface Area	31.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	32
Formal Charge	2
Complexity	508

SMILES

C1CCNC2=CC=[N+](CCCCC[N+]3=CC=C(C4=CC=CC=C43)NCC1)C5=CC=CC=C25

InChI

InChI=1S/C28H32N4/c1-7-17-29-25-15-21-31(27-13-5-3-11-23(25)27)19-9-2-10-20-32-22-16-26(30-18-8-1)24-12-4-6-14-28(24)32/h3-6,11-16,21-22H,1-2,7-10,17-20H2/p+2

InChIKey

IOXVWOJJNCBJBX-UHFFFAOYSA-P

Chemical Structure

2D Structure

CAS: 201147-53-7

CID: 9811445

Formula: C28H34N4+2

MW: 426.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	426.6
XLogP3	6.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	426.27834710
Monoisotopic Mass	426.27834710
Topological Polar Surface Area	31.8 Å²
Heavy Atom Count	32
Formal Charge	2
Complexity	508
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
TRC-U130595-5MG	UCL 1848
sc-253819A	UCL-1848 trifluoroacetate salt
ZHA93416-01	UCL 1684
T34981	UCL-2138
BUP15294-01	UCL 2077
MBS5778702	UCL-1972
BA8732-10	UCL-TRO-1938
A19981-50	UCL 2077 50mg
sc-253818	UCL 1684 ditrifluoroacetate

UCL-1848 (TFA)

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