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UCL 1684 (dibromide)

CAT: 0804-HY-108579-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108579-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness[1][2][3].
CAS Number
199934-16-2
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ucl-1684-dibromide.html
Purity
98.07
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=[N+](CC3=CC(C[N+]4=CC=C(NCC5=CC=C(C=C5)CN6)C7=CC=CC=C47)=CC=C3)C=CC6=C1C=CC=C2.[Br-].[Br-]
Molecular Formula
C34H30Br2N4
Molecular Weight
654.44
References & Citations
[1]Burashnikov A, et al. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020;76 (2) :164-172.|[2]Rosa JC, et al. Bis-quinolinium cyclophanes: 6,10-diaza-3 (1,3),8 (1,4) -dibenzena-1,5 (1,4) - diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca (2+) -activated K+ channel. J Med Chem. 1998;41 (1) :2-5.|[3]Diness JG, et al. Effects on atrial fibrillation in aged hypertensive rats by Ca (2+) -activated K (+) channel inhibition. Hypertension. 2011;57 (6) :1129-1135.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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