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Quinine (hydrobromide)

CAT: 0804-HY-B1751CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1751CSize:1 Each
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Description
Quinidine hydrobromide is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine hydrobromide is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine hydrobromide can be used for malaria research[1][2][3].
CAS Number
549-49-5
UNSPSC
12352005
Hazard Statement
H302-H312-H315-H317-H319-H332-H334-H335
Target
Cytochrome P450; Parasite; Potassium Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/quinine-hydrobromide.html
Solubility
10 mM in DMSO
Smiles
O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3.[H]Br
Molecular Formula
C20H25BrN2O2
Molecular Weight
405.33
Precautions
P261-P264-P270-P271-P272-P280-P284-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103 (3) :1807-13.|[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Plasmodium

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