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Quinine (hemisulfate hydrate)

CAT: 0804-HY-D0143BSize: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-D0143BSize:1 g
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Description
Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV, with an IC50 of 169 μM[1][2].
CAS Number
207671-44-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite; Potassium Channel
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/quinine-hemisulfate-hydrate.html
Purity
99.42
Solubility
H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H][C@@]1([C@H](O)C2=CC=NC3=C2C=C(OC)C=C3)C[C@H]4[C@@H](C=C)C[N@@]1CC4.OS(O)(=O)=O.O.[1/2]
Molecular Formula
C20H24N2O2.1/2H2O4S.H2O
Molecular Weight
391.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144.|[2]Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172 (17) :4355-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Plasmodium

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