Quinine (dihydrochloride)

• UNSPSC Description:

  Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].

• Target Antigen:

  Dengue virus; Flavivirus; Parasite; Potassium Channel

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/quinine-dihydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=C[C@H](C[N@@]1CC2)[C@H]2C[C@@H]1[C@H](O)C3=CC=NC4=CC=C(OC)C=C34.Cl.Cl

• Molecular Weight:

  397.34

• References & Citations:

  [1]Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.|[2]Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.|[3]Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  60-93-5