SHP2 protein degrader-2

SHP2 protein degrader-2

• CAS Number: 2740582-16-3
• UNSPSC Description: SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].
• Target Antigen: Phosphatase; PROTACs; SHP2
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/shp2-protein-degrader-2.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O
• Molecular Weight: 1115.89
• References & Citations: [1]Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022 Feb 24;65(4):3066-3079.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported