Hydroxypropyl Cellulose

• Description:

  Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC) . Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, IL-1β) . Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents; Interleukin Related

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Others

• Field of Research:

  Inflammation/Immunology; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/hydroxypropyl-cellulose.html

• Purity:

  97.0

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  CO[C@H]1C (O[R]) [C@@H] (O[R]) [C@H] (C) O[C@@H]1CO[R].[n].[R=H or CH2CH (OH) CH3]

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Werbowyj R S, et al. Liquid crystalline structure in aqueous hydroxypropyl cellulose solutions[J]. Molecular Crystals and Liquid Crystals, 1976, 34 (4) : 97-103.|[2]Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.|[3]Li X, et al. The potential therapeutic effects of hydroxypropyl cellulose on acute murine colitis induced by DSS. Carbohydr Polym. 2022 Aug 1;289:119430.|[4]Kim H, et al. Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice. J Agric Food Chem. 2013 Jul 3;61 (26) :6404-11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  9004-64-2