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Cav1.3 rabbit pAb

CAT: 0855-ES20797-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20797-01Size:50 µL
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Background
Calcium voltage-gated channel subunit alpha1 D (CACNA1D) Homo sapiens Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Description
Calcium voltage-gated channel subunit alpha1 D (CACNA1D) Homo sapiens Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
UniProt
Q01668
Swiss Prot
Q01668
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic Peptide of Cav1.3 AA range: 1060-1140
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC 1:100-200
Molecular Weight
245kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
245kD
Fragment
IgG
Subcellular Location
Membrane ; Multi-pass membrane protein .
Other Product Names
Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3)
Gene ID (Human)
776

UniProtKB · Q01668

Voltage-dependent L-type calcium channel subunit alpha-1D

CAC1D_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q01668
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CACNA1D
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B0FYA3, Q13916, Q13931, Q71UT1, Q9UDC3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Ligand

CalciumMetal-binding

Molecular function

Calcium channelIon channelVoltage-gated channel

Biological process

Calcium transportIon transportTransport

Disease

DeafnessDisease variantEpilepsy

PTM

Disulfide bondGlycoproteinPhosphoprotein

Cellular component

Membrane

Domain

RepeatTransmembraneTransmembrane helix

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