NBR1 Rabbit rabbit pAb
CAT:
855-ES20659-02
Size:
100 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NBR1 Rabbit rabbit pAb
- Description: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21. 1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],
- Synonyms: Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein;Membrane component chromosome 17 surface marker 2;Neighbor of BRCA1 gene 1 protein;Protein 1A1-3B)
- Gene ID: 4077
- UniProt: Q14596
- Cellular Locus: Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911)..
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Recombinant Protein of NBR1
- Clonality: Polyclonal
- Validated Applications: IHC, IF
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: IHC-p 1:50-300
- Molecular Weight: 120kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.