Rabbit anti Human Ribonucleoside-diphosphate reductase, large subunit (RRM1)

Rabbit anti Human Ribonucleoside-diphosphate reductase, large subunit (RRM1)

• Background: This protein is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in the S phase of dividing cells. The gene for RRM1 is, along with several others, located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region are associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. RRM1 plays an important role in malignancies and disease that involve this region.
• Synonyms: Ribonucleoside-diphosphate reductase subunit M1, EC=1.17.4.1, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1
• CAS Number: 9007-83-4
• UniProt: P23921
• Host: Rabbit
• Species Reactivity: Human
• Isotype: Ig
• Conjugation: Affinity Purified
• Type: Antigen Immunoaffinity Purified Polyclonal
• Applications: WB, IHC, ELISA
• Purification Method: Antigen Immunoaffinity Purification
• Assay Principle: This antibody can be used for immunohistochemistry on formalin/paraffin sections (10-15 µg/mL). Optimal concentration should be evaluated by serial dilutions.
• Stability: See expiration date on vial
• Concentration: See vial for Concentration
• Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
• Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
• Shipping Conditions: Ambient Temperature, freeze upon arrival
• Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
• Functional Analysis: IHC