Rabbit anti Human Ribonucleoside-diphosphate reductase, large subunit (RRM1)

• Background:

  This protein is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in the S phase of dividing cells. The gene for RRM1 is, along with several others, located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region are associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. RRM1 plays an important role in malignancies and disease that involve this region.

• Synonyms:

  Ribonucleoside-diphosphate reductase subunit M1, EC=1.17.4.1, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1

• UniProt:

  P23921

• Host:

  Rabbit

• Species Reactivity:

  Human

• Isotype:

  Ig

• Conjugation:

  Affinity Purified

• Type:

  Antigen Immunoaffinity Purified Polyclonal

• Applications:

  WB, IHC, ELISA

• Purification Method:

  Antigen Immunoaffinity Purification

• Assay Principle:

  This antibody can be used for immunohistochemistry on formalin/paraffin sections (10-15 µg/mL). Optimal concentration should be evaluated by serial dilutions.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  IHC

• CAS Number:

  9007-83-4