Mps-BAY2a

• Description:

  Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Mps1

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mps-bay2a.html

• Purity:

  99.30

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C(C1=CC=C(C2=CN=C3C(NCC(C)C)=NC(C4=C5C=CC=NC5=CC=C4)=CN32)C=C1)NC6CC6

• Molecular Formula:

  C29H28N6O

• Molecular Weight:

  476.57

• References & Citations:

  [1]Jemaà M, et al. Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 2013 Nov;20 (11) :1532-45.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1382477-96-4]